ACESSO ABERTO
Corynebacterium pseudotuberculosis é o agente etiológico causador da linfadenite ou pneumonia em humanos e da linfadenite caseosa em caprinos e ovinos. Os atuais diagnósticos sorológicos para animais apresentam protocolos de baixa especificidade e sensibilidade, e em humanos é inexistente qualquer kit de diagnóstico desta natureza. Esta doença, de curso crônico nos caprinos e ovinos, caracteriza-se pela formação de granulomas nos linfonodos e em órgãos internos, como forma de resposta do sistema imune do hospedeiro à penetração deste agente que resiste à ação bactericida das células fagocíticas. A presente revisão de literatura propõe uma abordagem dos aspectos da Linfadenite Caseosa em pequenos ruminantes desenvolvendo informações sobre características morfofuncionais do agente etiológico, suas interações e mecanismos e influência nos parâmetros clínico-epidemiológicos, etiopatogenia, sinais clínicos, diagnóstico e controle.
Palavras-chave: Corynebacterium pseudotuberculosis, caprino, diagnóstico, ovinocultura, zoonose.
Corynebacterium pseudotuberculosis is the etiological agent that causes lymphadenitis or pneumonia in humans and caseous lymphadenitis in goats and sheep. Current serological diagnostics for animals present protocols of low specificity and sensitivity, and there is no diagnostic kit of this nature for humans. This disease, which has a chronic course in goats and sheep, is characterized by the formation of granulomas in the lymph nodes and internal organs as a response of the host's immune system to the penetration of this agent that resists the bactericidal action of phagocytic cells. This literature review proposes an approach to the aspects of caseous lymphadenitis in small ruminants, developing information on the morphofunctional characteristics of the etiological agent, its interactions and mechanisms, and influence on clinical-epidemiological parameters, etiopathogenesis, clinical signs, diagnosis, and control.
Keywords: Corynebacterium pseudotuberculosis, diagnosis, goat, sheep farming, zoonosis.
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